Η εμπειρία αποδεικνύει ότι όταν για βαθιές ρυτίδες στο μεσόφρυο συνδυάζονται βοτουλινικής τοξίνης με εμφύτευμα υαλουρονικού οξέος η βελτίωση είναι πολύ μεγαλύτερη. Επίσης διαρκεί περισσότερο διάστημα το αποτέλεσμα της θεραπείας και χρειάζονται πιο αραιές επαναλήψεις και μικρότερη ποσότητα υλικών.
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